6.Follow up on development of hyperglycemia in subjects with impaired glucose tolerance (IGT)

  Glycemia often deteriorates accompanied with glucose spike in prediabetic conditions over the years.1,5-AG reduction is related to the degree of impairment of glucose tolerance in IGT subjects too.

 1,5-AG decreases although it remains within normal limits in response to deterioration of glucose spike.

  Monitoring of 1,5-AG once a year enable the detection of progression of IGT to diabetes mellitus.

  Diagnosis of IGT is based mainly on OGTT results. Because implementation of OGTT takes time and cost, primary screening by 1,5-AG is useful.

  Simple screening for IGT and diabetes by saliva 1,5AG concentration may be realized in future (JCEM 105, 1759, 2020)

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