• １．Improvement of glucose spike (postprandial hyperglycemia ) can not be sufficiently detected by HbA1c or glycoalbumin (fructosamine)
• ２．Why only 1,5-anhydroglucitol(1,5-AG) can detect glucose spike?
• ３．Measuring 1,5-AG weekly, monthly, even yearly is effective in management of diabetes mellitus
• ４．1,5-AG of less than 14 μg/ml indicates existence of glucose spike even in near-normoglycemia
• ５．Rapid and wide variations of 1,5-AG make your clinical decision robust
• ６．Follow up on development of hyperglycemia in subjects with impaired glucose tolerance (IGT)
• ７．"Your glycemia is stable" → No!!
• ８．The value of approximate mean postmeal maximum plasma glucose levels corresponding to 1,5-AG
• ９．Hypoglycemia and 1,5-AG
• １０．Combination measurement with 1,5-AG and HbA1c
• １１．Factors that cause an abnormal value
• １２．What is 1,5-Anhydroglucitol (1,5-AG ) ?
• １３．Physiological role
• １４．1,5-AG and diabetic complications

６．Follow up on development of hyperglycemia in subjects with impaired glucose tolerance (IGT)

  Glycemia often deteriorates accompanied with glucose spike in prediabetic conditions over the years.1,5-AG reduction is related to the degree of impairment of glucose tolerance in IGT subjects too.

 1,5-AG decreases although it remains within normal limits in response to deterioration of glucose spike.

  Monitoring of 1,5-AG once a year enable the detection of progression of IGT to diabetes mellitus.

  Diagnosis of IGT is based mainly on OGTT results. Because implementation of OGTT takes time and cost, primary screening by 1,5-AG is useful.

  Simple screening for IGT and diabetes by saliva 1,5AG concentration may be realized in future (JCEM 105, 1759, 2020)

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