12.What is 1,5-Anhydroglucitol (1,5-AG ) ?

  One of the major polyols estimated to be contained 500~1000 mg in the human body.

  Nearly all of it exists in the free form ( not bind to neither sugars nor proteins), in all organs and tissues.

  Resembling glucose in structure, but metabolically very stable because of lacking an open form

  De novo synthesis is minimal.

  Originates primarily in the diet.

  Reabsorbed 99.9% by the renal tubules, and this reabsorption competes with that of glucose in case of hyperglycemia.

  In renal tubules, the transporter (SGLT4) common to 1,5-AG, fructose, and mannose is thought to be located downstream of the main glucose transport system (BBA1291,89,1996, Life Sci 76, 1039, 2005).

  It has been suggested that general somatic cells possess a 1,5-AG specific transport system (J Biol Chem 269, 9664, 1994), whereas pancreatic β-cells possess a glucose-sensitive transport system for 1,5-AG (BBA 1474, 291, 2000).

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