• １．Improvement of glucose spike (postprandial hyperglycemia ) can not be sufficiently detected by HbA1c or glycoalbumin (fructosamine)
• ２．Why only 1,5-anhydroglucitol(1,5-AG) can detect glucose spike?
• ３．Measuring 1,5-AG weekly, monthly, even yearly is effective in management of diabetes mellitus
• ４．1,5-AG of less than 14 μg/ml indicates existence of glucose spike even in near-normoglycemia
• ５．Rapid and wide variations of 1,5-AG make your clinical decision robust
• ６．Follow up on development of hyperglycemia in subjects with impaired glucose tolerance (IGT)
• ７．"Your glycemia is stable" → No!!
• ８．The value of approximate mean postmeal maximum plasma glucose levels corresponding to 1,5-AG
• ９．Hypoglycemia and 1,5-AG
• １０．Combination measurement with 1,5-AG and HbA1c
• １１．Factors that cause an abnormal value
• １２．What is 1,5-Anhydroglucitol (1,5-AG ) ?
• １３．Physiological role
• １４．1,5-AG and diabetic complications

１．Improvement of glucose spike (postprandial hyperglycemia ) can not be sufficiently detected by HbA1c or glycoalbumin (fructosamine)

  α-glucosidase inhibitor (α-GI) is well-known to reduce glucose spike (postprandial glycemia) in patients with diabetes.

  The slides above show that theseα-GI ,such as voglibose or miglitol (not acarbose; mentioned later), lowered
HbA1c but only by 0.4%, or glycoalbumin (fructosamine) by 1.0 %.

  1,5-AG(GlycoMark)，however, markedly (4.0→10.0μg/ml) improved in the same group.

  Unlike HbA1c and glycoalbumin, 1,5-AG can easily catch the change of glucose spike, separately from average blood glucose.

  We often find that 1,5-AG normalize after the treatment of α-GI, while HbA1c is stable within normal range, in lean (especially woman) or elderly subjects.

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